Doublet frequencies in evolutionary distinct groups
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 12 (3) , 1749-1763
- https://doi.org/10.1093/nar/12.3.1749
Abstract
We analyze the dinucleotide frequencies of occurrence and preferences separately within the vertebrates, nonvertebrates, DNA viruses, mitochondria, RNA viruses, bacteria and phage sequences. Over half a million nucleotides from more than 400 sequences were used in this study. Distinct patterns are observed. Some of the patterns are common to all sequences, some to either eukaryotes or prokaryotes and others to the subgroups within them. Doublets are the most basic ingredient of order in nucleotide sequences. We suggest that their preferences and the arrangement of nucleotides in the DNA in general is determined to a large extent by the conformational and packaging considerations of the double helix. Some principles of DNA conformation are viewed in light of our results.Keywords
This publication has 12 references indexed in Scilit:
- A Markov analysis of DNA sequencesJournal of Theoretical Biology, 1983
- Some indications for inverse DNA duplicationJournal of Theoretical Biology, 1982
- Kinematic model for B-DNA.Proceedings of the National Academy of Sciences, 1981
- Structure of a B-DNA dodecamerJournal of Molecular Biology, 1981
- Nearest neighbor nucleotide patterns. Structural and biological implications.Journal of Biological Chemistry, 1981
- Structure of a B-DNA dodecamerJournal of Molecular Biology, 1981
- Structure of a B-DNA dodecamer: conformation and dynamics.Proceedings of the National Academy of Sciences, 1981
- Some rules in the ordering of nucleotides in the DNANucleic Acids Research, 1980
- How many base-pairs per turn does DNA have in solution and in chromatin? Some theoretical calculations.Proceedings of the National Academy of Sciences, 1978
- The Role of DNA Structure in Genetic RegulatioCRC Critical Reviews in Biochemistry, 1977