Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages
Open Access
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (6) , 2325-2330
- https://doi.org/10.1128/aac.48.6.2325-2330.2004
Abstract
We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.Keywords
This publication has 23 references indexed in Scilit:
- Rapid and Efficient Cell-to-Cell Transmission of Human Immunodeficiency Virus Infection from Monocyte-Derived Macrophages to Peripheral Blood LymphocytesVirology, 1999
- Potential for the Transmission of HIV-1 despite Highly Active Antiretroviral TherapyNew England Journal of Medicine, 1998
- Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV‐1‐infected cellsFEBS Letters, 1996
- Inhibition of Human Immunodeficiency Virus Replication in Differentiating Monocytes by Interleukin 10 Occurs in Parallel with Inhibition of Cellular RNA ExpressionAIDS Research and Human Retroviruses, 1996
- Function of human immunodeficiency virus type 1 Vpu protein in various cell typesJournal of General Virology, 1995
- Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 IsolateVirology, 1994
- Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses.Proceedings of the National Academy of Sciences, 1993
- Changes in the Host Range and Growth Potential of an HIV-1 Clone Are Conferred by the vpu GeneVirology, 1993
- A Novel Gene of HIV-1, vpu , and Its 16-Kilodalton ProductScience, 1988
- Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA PolymeraseScience, 1988