Fast Amide Cleavage under Mild Conditions: An Evolutionary Approach to Bioorganic Catalysis
- 18 February 1994
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 33 (3) , 346-348
- https://doi.org/10.1002/anie.199403461
Abstract
The noncovalent aggregation of hexadecanoate in aqueous phosphate buffer with 3% acetonitrile gives rise to “catalytic clumps” that catalyze the hydrolysis of the amide group in 1. Amide cleavage is achieved with 108‐fold acceleration with catalyst concentrations of 10−5M at pH 7–8. These extremely simple catalysts, whose activity equals or exceeds that of catalytic antibodies, were found by rapid screening of hundreds of organic “clumps”. equation imageKeywords
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