Contact allergy from propylene glycol

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Abstract
Propylene glycol (PG) 20% in water was tested in 400 subjects with eczematous contact dermatitis. In 6 inpatients (1.5%) reactions were recorded as positive according to the following criteria: relevant history of prolonged contact with PG-containing topical pharmaceutical and cosmetic preparations; reaction extended in time outside the area of application of the test substance, and persisted locally for several days; a similar reaction was obtained on repetition of the test with a lower concentration of PG; prompt improvement in clinical manifestations of eczema on withdrawal of PG-containing topical preparations. With the PG concentration employed no irritant reactions were observed.

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