A survey of P1-antibodies in Scottish pigeon fanciers

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Abstract
The incidence and characteristics of P1-antibodies in Scottish fanciers were assessed. Of 223 individuals participating in the study, 23.3% were P1-negative, and of these, 53.9% had detectable P1-antibodies. These antibodies belonged to the IgM class, and the highest serum levels were found in those pigeon fanciers with symptoms of respiratory disease who were sensitized to pigeon antigens. Of pigeon fanciers'' sera, 10.3% gave false-positive reactions for the hepatitis B surface antigen in a reversed passive hemagglutination test. The reactions were most prevalent in sensitized fanciers and were directed not against the absorbed HBsAg antibody, but against the turkey red cells used as carriers in the test. No relationship was observed between the existence of P1-antibodies and false-positive hepatitis reactions. The inhalation of avian antigens by pigeon fanciers can induce the production of at least 3 distinct populations of antibodies. No evidence was obtained to imply any special role for P1-antibodies in the etiology of pigeon fanciers'' disease.