Induction of differentiation of leukaemic (HL‐60) or prostate cancer (LNCaP, JCA‐1) cells potentiates apoptosis triggered by onconase

Abstract
Onconase (Onc) is a ribonuclease from amphibian oocytes that is cytostatic and cytotoxic to many tumour lines. It shows in vivo antitumour activity in mouse tumour models and is currently in Phase II...

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