Renal Sorbitol Accumulation and Associated Enzyme Activities in Diabetes
- 1 July 1988
- journal article
- research article
- Published by S. Karger AG in Enzyme
- Vol. 39 (4) , 231-234
- https://doi.org/10.1159/000469124
Abstract
Streptozotocin-induced diabetes increased sorbitol levels in the rat renal medulla. The activities of renal medullary aldose reductase and sorbitol dehydrogenase, responsible for the formation and metabolism of sorbitol, favor sorbitol formation and did not change in diabetes. The elevated sorbitol concentration appears to be due to an increase in medullary glucose concentration.This publication has 3 references indexed in Scilit:
- Induction of aldose reductase and sorbitol in renal inner medullary cells by elevated extracellular NaCl.Proceedings of the National Academy of Sciences, 1987
- Rat lens aldose reductase: rapid purification and comparison with human placental aldose reductaseExperimental Eye Research, 1983
- Human Brain Aldehyde Reductases: Relationship to Succinic Semialdehyde Reductase and Aldose ReductaseJournal of Neurochemistry, 1980