MULTIPLE MYELOMA WITH BONE MARROW PLASMA CELLS IN THE BLOOD

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Abstract
CLINICAL OBSERVATIONS, BY DR. BECK Owing to the fact that Bence-Jones proteinuria and multiple myeloma are conditions of rare occurrence, one not only should feel justified, but also should feel it a duty to the profession to report individual cases, especially so long as we need more light on the pathologic and clinical features of the disease. The case herewith reported is of special significance since bone marrow plasma cells were found in the circulating blood by one of us, a condition rarely seen. An examination of the literature for the history of cases of multiple myeloma makes it evident that the disease, although rare, has not often been recognized. Thirty-seven years elapsed between the time Bence-Jones discovered the phenomenon in the urine, in 1846, and the report of the second case by Kuhne. Fifty years after the discovery, only four authenticated cases were added to the literature. In the

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