Evidence of an α2‐macroglobulin‐like molecule in plasma of Salamandra salamandra Structural and functional similarity with human α2‐macroglobulin
- 13 July 1987
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 219 (1) , 37-39
- https://doi.org/10.1016/0014-5793(87)81186-9
Abstract
A high‐Mr (M r 750 000) α1 ‐macroglobulin, obtained from Salamandra salamandra, is described. Salamander α1‐macroglobulin is composed of two monomers of equal M r, which are composed of two polypeptide chains, each of M r 180 000, linked by disulfide bonds. The molecular parameters of this protein, its binding to trypsin and inactivation by methylamine suggest that salamander α1‐macroglobulin is closely related to human α2‐macroglobulin and to other related proteins described in the animal kingdom.Keywords
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