Antibacterial Activity of Acyclic Decapeptide Analogs of Gramicidin S
- 4 March 1960
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 131 (3401) , 669-670
- https://doi.org/10.1126/science.131.3401.669
Abstract
Three acyclic decapeptide analogs of gramicidin S, although found to possess antibacterial activity, apparently have modes of action which differ from that of the naturally occurring cyclic antibiotic. In contrast to the immediate action of gramicidin S, one of the decapeptides produced complete bacteriostasis only after several cell divisions had occurred. Furthermore, mixtures of gramicidin S with either of two of the acyclic peptides were synergistic. Some implications of these findings are discussed.Keywords
This publication has 10 references indexed in Scilit:
- Synthesis of Peptides Related to Gramicidin S. III.1 The Decapeptide Containing L-Lysine Residues in Place of L-Ornithine2Journal of the American Chemical Society, 1959
- Synthesis of Peptides Related to Gramicidin S. II.1 The Decapeptide Containing D-Tyrosine Residues in Place of D-Phenylalanine2Journal of the American Chemical Society, 1958
- Ein synthetisches Analoges des Gramicidins S: C‐(Val‐Lys‐Leu‐Phe‐Pro)2, (L‐L‐L‐D‐L)2. 6. Mitteilung über homodet cyclische PolypeptideHelvetica Chimica Acta, 1958
- Synthesis of L-4-amino-3-isoxazolidinone, the unnatural stereoisomer of cycloserine and its antibiotic activityCellular and Molecular Life Sciences, 1957
- The antibacterial action of some basic amino acid copolymersArchives of Biochemistry and Biophysics, 1956
- Effect of vitamins on the acute toxicity of hydrazine derivativesCellular and Molecular Life Sciences, 1956
- Antibiotically Active Amino-Acid Copolymers related to Gramicidin SNature, 1955
- Gramicidin S: Relationship of Cyclic Structure to Antibiotic ActivityNature, 1954
- The Synthesis of Peptides Related to Gramicidin SJournal of the American Chemical Society, 1954
- A Quantitative Analysis of Sulfonamide BacteriostasisScience, 1942