Determination of Dexamethasone in Milk by High Pressure Liquid Chromatography

1 January 1977

journal article
research article
Published by Oxford University Press (OUP) in Journal of AOAC INTERNATIONAL

Vol. 60 (1) , 210-212
https://doi.org/10.1093/jaoac/60.1.210

Abstract

A rapid and sensitive high pressure liquid chromatographic method for the analysis of dexamethasone (9α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione) in milk has been developed. The corticosteroid can be quantitated at 20 ppb, with the limit of detectability estimated at 5 ppb. Recoveries ranged from 72 to 94%. After dexamethasone was injected into 5 Holstein-Friesian cows, no residues were found in milk, even after the first milking.

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