C-PEPTIDE SUPPRESSION TEST FOR INSULINOMA

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 90  (1) , 180-186
Abstract
During hypoglycemia induced by infusion of porcine insulin, impaired suppression of endogenous insulin secretion as measured by C-peptide was demonstrated in 11 of 12 patients with insulinoma. During hypoglycemia (plasma glucose .ltoreq. 40 mg/dl) the mean C-peptide immunoreactivity (CPR) of normal subjects was .ltoreq. 1.2 ng/ml, whereas 11 of 12 insulinoma patients had a mean CPR of .gtoreq. 1.9 ng/ml. One patient showed normal CPR suppression by these criteria but may have shown impaired CPR suppression for glucose .ltoreq. 30 mg/dl. Impaired CPR suppression during insulin induced hypoglycemia may prove to be a useful test for insulinoma.

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