NMR studies of the Na+, Mg2+ and Ca2+ complexes of cyclosporin A
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1682-1684
- https://doi.org/10.1039/c39920001682
Abstract
The immunosuppressant cyclosporin A has been shown by NMR spectroscopy to form complexes with Na+, Ca2+ and Mg2+ in acetonitrile; Ca2+ and Mg2+ form 1 : 1 complexes and the conformation of cyclosporin A changes dramatically upon binding of the metal ions.Keywords
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