Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?
- 1 October 2003
- journal article
- research article
- Published by Springer Nature in Neurological Sciences
- Vol. 24 (3) , 192-193
- https://doi.org/10.1007/s10072-003-0125-z
Abstract
We examined the potential sex-related differences in levodopa pharmacokinetics and their relation with the presence of dyskinesias in a group of 115 patients (67 men, 49 women) with Parkinson’s disease. The patients were given a standard oral dose of levodopa plus benserazide (100/25 mg). The area under the levodopa plasma concentration time curve, corrected for the levodopa test dose (in mg/kg body weight), (AUCw) was significantly higher in women than in men, with a reduced oral clearance. No difference in the proportion of men and women experiencing dyskinesias was observed.Keywords
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