Postoperative Hypofibrinogenemia

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Abstract
IN the process of coagulation in vivo, or in vitro, the clotting of fibrinogen is the only directly observable stage of a chain reaction comprising many stages. This well defined protein has been available in a relatively stable and highly purified form after its separation from pooled plasma. Its principal use to date has been for intravenous administration to correct congenital or acquired fibrinogenopenic states. The majority of these cases fall into the latter group, are associated with a demonstrable fibrinolysin and are most numerous in obstetrics.1 2 3 The general surgical literature is growing in this regard also,4 5 6 most cases being . . .