Detection of Epstein-Barr viral DNA internal repeats in the nasopharyngeal mucosa of chinese with IgA/ebv-specific antibodies

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Abstract
Fifty-six South Chinese individuals exhibiting IgA antibodies to EBV for 18 months and presenting naso-pharyngeal abnormalities were biopsied. Four nasopha-ryngeal carcinomas, two at a very early stage, were detected. In 14 further individuals, without clinical or his-topathological evidence of tumor, EBV/DNA internal repeats and/or EBNA were detected in the biopsied mucosae. The presence of IgA/EBV antibodies and/or EBV markers in the nasopharyngeal mucosa may characterize pre-cancerous conditions.