THE PROLACTIN RESPONSE TO METOCLOPRAMIDE IN GROWTH HORMONE DEFICIENT ADOLESCENT MALES

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Abstract
The growth hormone (GH) and prolactin (PRL) responses following administration of 10 mg i.v. metoclopramide (MCP) (Maxolon) were examined in 30 adolescent males with short stature and delayed puberty, 8 of whom have isolated growth hormone deficiency. Peak GH and PRL levels following stimulation were highly significantly correlated when all subjects were analyzed together (r = 0.61, P < 0.001) but when the responses of the GH deficient and non-deficient groups of subjects were analyzed separately no significant correlation was obtained (P > 0.1), this reflected the fact that the PRL response to MCP was significantly lower in the GH deficient group (P < 0.0002). In addition 2 boys who demonstrated biochemical GH deficiency prior to puberty only, showed PRL responses similar to boys with normal GH reserves. The PRL response to MCP may be of value in the assessment of stimulation tests of GH reserve, as well as in the selection of patients for treatment with GH.