Cancer-Induced Alterations in T-Cell Subsets in Normal and Cyclophosphamide-Treated Mice
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 85 (2) , 180-183
- https://doi.org/10.1159/000234499
Abstract
The influence of an ascites carcinoma on splenic T-cell subsets in normal or cyclophosphamide (Cy)-pretreated mice immunized with sheep erythrocytes was determined by immunophenotypic analysis, using an ‘EPICS C’ flow cytometer. As suggested by our previous studies on lymphokine production, the results obtained were consistent with direct impairment of Th-cell function and/or with tumour-induced suppression of cell-mediated immunity by Cy-insensitive suppressor cells, such as the ‘Ts effector’ (Ts3) or those of non-T-cell lineage.This publication has 9 references indexed in Scilit:
- A syngeneic splenic cell antigen induces a suppressor T cell in lymph nodes that controls cytotoxic T-cell and primary antibody responsesCellular Immunology, 1987
- Characterization of the accessory cells involved in suppressor T cell induction.The Journal of Immunology, 1985
- Tumour-Induced Suppression of Delayed-Type Hypersensitivity in the Mouse: Independence of Cyclophosphamide-Sensitive Suppressor CellsInternational Archives of Allergy and Immunology, 1985
- Interleukin 2 (IL-2) activity during tumor growth: IL-2 production kinetics, absorption of and responses to exogenous IL-2Cellular Immunology, 1984
- Augmentation of delayed-type hypersensitivity reactions to ovalbumin by cyclophosphamide in the mouse: Strain variability, antigen specificity and nature of the suppressor cellAnnales de l'Institut Pasteur / Immunologie, 1983
- Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.The Journal of Experimental Medicine, 1982
- Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo.The Journal of Experimental Medicine, 1981
- Difference in thymus dependency between effector and suppressor T cells for delayed footpad reaction to sheep erythrocytes in miceCellular Immunology, 1981
- Cyclophosphamide eliminates suppressor T cells in age-associated central regulation of delayed hypersensitivity in mice.The Journal of Experimental Medicine, 1979