Chemical modification of coriolin B.
- 1 January 1977
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 30 (1) , 59-65
- https://doi.org/10.7164/antibiotics.30.59
Abstract
Several derivatives of 5-ketocoriolin B chemically modified at C-8 were synthesized. These derivatives showed antitumor [mouse L-1210 leukemia] and antibacterial activity of the same degree as 5-ketocoriolin B and diketocoriolin B, which were the most active members of the known coriolin group antibiotics. These derivatives were more stable than 5-ketocoriolin B and diketocoriolin B in acidic or alkaline solution.This publication has 0 references indexed in Scilit: