Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.
Open Access
- 1 August 1995
- journal article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 71 (4) , 244-246
- https://doi.org/10.1136/sti.71.4.244
Abstract
OBJECTIVE--To determine the kinetics of azithromycin in cervical mucus and plasma. SUBJECTS AND METHODS--Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose. RESULTS--In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14. CONCLUSION--The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.Keywords
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