Inoculation of Calves With Particles Resembling C-Type Virus From Cultures of Bovine Lymphosarcoma2
- 1 February 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 48 (2) , 423-428
- https://doi.org/10.1093/jnci/48.2.423
Abstract
Lymphocyte cultures containing particles resembling C-type virus particles were prepared from 3 cows that died with lymphosarcoma and from 2 experimentally inoculated calves. Fourteen calves were inoculated parenterally (one with cell-free material) and two were exposed orally. Cultures of circulating lymphocytes were examined regularly after inoculation, and C-type-like particles were detected in all calves wifhin 13 months. Five calves developed persistent lymphocytosis which first appeared 4–13 months after inoculation.Keywords
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