THE RESISTANCE OF ERYTHROCYTES IN NORMAL RABBITS AND GUINEA-PIGS

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Abstract
Several times one of us has made the observation that in acute hemorrhagic dyscrasia (purpura hemorrhagica, severe anemia, etc.1) when purpura is present, a decrease in the resistance of the red cells to hypotonic salt solution frequently occurs. This has been quite marked at times and has led us to believe that there is a direct association between changes in the red cell resistance and the occurrence of purpura. Furthermore, as we have observed changes in the resistance only during the acute onset of purpura, or while the purpura was developing and not during subsidence of the symptoms, it has occurred to us that the decreased resistance might be a factor in the pathogenesis of the purpuric lesion. The present work was therefore undertaken in order to determine whether or not in experimental conditions simulating purpura in man such changes in the resistance of the red cells are constant.

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