Epidemic Influenza B and G in Navy Recruits, 1953-1954. II. Antigenic Studies on Influenza Virus, Type C.

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Abstract
Between the 16th of Dec, 1953 and 16th April 1954 thirty-one strains of influenza virus type C were isolated in embryonated eggs from nasal washings of Navy recruits with a variety of respiratory illnesses. A significant increase in hemagglutination-inhibition (HI) or complement-fixation (CF) antibody titer occurred in the blood sera of 27 of the 29 individuals from whom bleedings had been obtained. Influenza C viruses were isolated before, during, and after an influenza B epidemic. While the influenza B epidemic was of 3 weeks duration, the influenza C viruses were isolated over a period of 17 weeks. A comparison of the strains of influenza C viruses isolated in 1950 (JJ), 1952 (GL 899), and 1954 (GL 1167) indicates that they have not changed antigenically insofar as can be determined by the CF and HI tests using human sera against the 3 strains.

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