Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes

This publication has 13 references indexed in Scilit:

• SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1
  Published by Wiley ,2000
• The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
  Chemistry & Biology, 1997
• A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
  Nature Structural & Molecular Biology, 1997
• Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase
  Bioorganic & Medicinal Chemistry, 1997
• 1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency
  Journal of Medicinal Chemistry, 1996
• A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
  Nature, 1994
• Bicyclic Imidazoles as a Novel Class of Cytokine Biosynthesis Inhibitors
  Annals of the New York Academy of Sciences, 1993
• Inhibitors of Cytochrome P-450s and Their Mechanism of Action
  Drug Metabolism Reviews, 1981
• Chemistry of sulfonylmethyl isocyanides. 12. Base-induced cycloaddition of sulfonylmethyl isocyanides to carbon,nitrogen double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imidazoles from aldimines and imidoyl chlorides
  The Journal of Organic Chemistry, 1977
• Synthesen in der heterocyclischen Reihe, IV. Synthesen heterocyclischer Aldehyde. Pyrimidinaldehyd‐(4)
  European Journal of Inorganic Chemistry, 1964