Gene duplication at an isocitrate dehydrogenase locus in Scaphiopus

Abstract
Spadefoot toads of the subgenus Scaphiopus have two isocitrate dehydrogenase loci, with no intergenic inter-action between them. Toads of the subgenus Spea have three ldh loci. with intergenic enzymes formed between two of them, providing strong evidence for their homology and the origin of one through a duplication process. The ldh phenotype of interspecific hybrids is consistent with the theory of a gene duplication.

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