Reduction of Urinary Sodium and Potassium of Diabetic Rats Produced by Hypophyseal Growth Hormone.

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Abstract
Four groups of 4 or 5 animals each of partially de-pancreatized diabetic rats were studied. Each animal was fed a constant daily diet and urines were analyzed daily for glucose, N, Na, and K. The administration of GH at dose levels of either 3 or t mg. per day produced a reduction of urinary Na and K in all groups. The reduction was statistically significant (p<.01) in 2 of 6 experiments for Na and in 6 of 6 for K. This occurred even when the glycosuria was concomitantly increased in 5 of 6-experiments. In all experiments significant N retention occurred.