Acute and Protracted Anaphylactic Shock After Subcutaneous Challenge in Random-Bred and Inbred Guinea Pigs

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Abstract
Shock after subcutaneous challenge of actively or passively sensitized guinea pigs may be either acute (characterized by bronchospasm) or protracted (characterized by symptoms such as intestinal hemorrhage) or a mixture of both. It is argued that the former occurs if antigen is quickly absorbed and freely reaches the lung tissue and the latter if excess circulating antibody or other factors prevent antigen being available in the lungs. A variety of quantitative experiments are presented to prove this point[long dash]Guinea pigs of "strain 2" are compared with the Hartley strain (random bred). The former produces as much circulating antibody as the latter, but is less susceptible to shock and tends to produce the protracted type of shock.

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