The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-rafcarrying retrovirus
Open Access
- 1 January 1987
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 15 (2) , 595-609
- https://doi.org/10.1093/nar/15.2.595
Abstract
The complete 606 amino acid sequence of the human A-raf oncogene has been deduced from the 2453 nucleotide sequence of a human T cell cDNA. A cysteine-rich region located near the amino terminus, which is highly conserved in A-raf and c-raf. shows significant homology with protein kinase C. A 5′ deleted fragment of the cDNA has been incorporated into a murine retrovirus which endows the virus with the ability to transform cells in vivo and in vitro. Functionally, human A-raf is similar to v-raf and v-mos in that transformation is independent of ras gene function.Keywords
This publication has 41 references indexed in Scilit:
- Chromosomal patterns in a benign human neoplasm, the mixed salivary gland tumourHereditas, 2008
- Cloning and expression of multiple protein kinase C cDNAsCell, 1986
- Protein kinase C activation by diacylglycerol second messengersCell, 1986
- Interaction between Raf and Myc oncogenes in transformation in vivo and in vitroJournal of Cellular Biochemistry, 1986
- Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-rafNature, 1984
- The Human Homologs of the raf ( mil ) Oncogene Are Located on Human Chromosomes 3 and 4Science, 1984
- X-Linked Lymphoproliferative Syndrome Registry reportThe Journal of Pediatrics, 1980
- Imbalance in X-Chromosome Expression: Evidence for a Human X-Linked Gene Affecting Growth of Hemopoietic CellsScience, 1979
- Acute leukemia and preleukemia in eight males in a family: An X‐linked disorder?American Journal of Hematology, 1979
- A fatal X-linked recessive reticuloendothelial syndrome with hyperglobulinemia: X-linked recessive reticuloendotheliosisThe Journal of Pediatrics, 1973