Promotion of Trophoblast Stem Cell Proliferation by FGF4
- 11 December 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 282 (5396) , 2072-2075
- https://doi.org/10.1126/science.282.5396.2072
Abstract
The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.Keywords
This publication has 34 references indexed in Scilit:
- FGF is an essential regulator of the fifth cell division in preimplantation mouse embryosDevelopmental Biology, 1998
- The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesisNature Genetics, 1998
- Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesisMechanisms of Development, 1996
- Isolation and characterization of a feeder-dependent, porcine trophectoderm cell line obtained from a 9-day blastocystPlacenta, 1995
- Essential role of Mash-2 in extraembryonic developmentNature, 1994
- Non-injection methods for the production of embryonic stem cell-embryo chimaerasNature, 1993
- Localization of Placental Lactogen-l in Trophoblast Giant Cells of the Mouse Placenta1Biology of Reproduction, 1991
- Expression pattern of the mouse T gene and its role in mesoderm formationNature, 1990
- Development of extraembryonic cell lineages in the mouse embryoPublished by Cambridge University Press (CUP) ,1987
- Control of trophoblastic growthPlacenta, 1983