An efficient and diastereoselective method for the synthesis of (R)-1-ferrocenylethylamines and 1-ferrocenylethyl acetate
- 1 January 1990
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 12,p. 888-889
- https://doi.org/10.1039/c39900000888
Abstract
The imine formed from 1-acetylferrocene and (R)-(+)-1-phenylethylamine undergoes a highly diastereoselective reduction with sodium borohydride to give, after a single recrystallisation, diastereoisomerically pure (R,R) amine (2a), which has been converted to (R)-(–)-1-ferrocenylethyl acetate in high optical purity (>98%).Keywords
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