The Evolution of Dominance

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Abstract
Fisher''s theory that the usual dominance of type genes is a consequence of the action of selection upon modifiers is criticized on the ground that the selection pressure due to this cause would ordinarily be of the second order relative to mutation pressure, or to the selection pressures to be expected as a rule from other of the presumably multiple effects of the modifier, or even to the random variations of gene frequency to be expected unless the interbreeding population is very large. A formula is given for the distribution of gene frequencies as related to size of population and to rates of selection and mutation.

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