Synthesis of N-Hydroxy α-Amino Acids from α-Hydroxy Acids with High Enantiomeric Purity
- 1 June 1995
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1995 (06) , 633-634
- https://doi.org/10.1055/s-1995-5031
Abstract
An efficient synthesis of N-alkoxycarbonyl-O-alkoxycarbonyl and N-hydroxy α-amino acids has been developed utilizing a Mitsunobu reaction and N-alkoxycarbonyl-O-alkoxycarbonyl hydroxylamines as nucleophiles. The method also gives access to D- or L-α-amino acids by reductive cleavage of the N-hydroxy derivatives.Keywords
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