Aberrant Interleukin-1 Receptors in a Cortisol-Secreting Adrenal Adenoma Causing Cushing's Syndrome
Open Access
- 2 July 1998
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 339 (1) , 27-31
- https://doi.org/10.1056/nejm199807023390105
Abstract
Cortisol-secreting adrenal adenomas are an uncommon cause of Cushing's syndrome. Little is known about the events leading to the formation of these tumors, but molecular defects, including activating mutations of receptors for corticotropic factors, have been suspected in this process. Structural mutations of the corticotropin-receptor gene have not been detected in these tumors,1 but some have had gastric inhibitory polypeptide,2,3 vasopressin,4 and more recently, β-adrenergic receptors.5Keywords
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