γ‐Tocotrienol Metabolism and Antiproliferative Effect in Prostate Cancer Cells
- 1 December 2004
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1031 (1) , 391-394
- https://doi.org/10.1196/annals.1331.054
Abstract
In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude alpha-T<alpha-T3<gamma-T<gamma-T3. The partial inhibition of gamma-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.Keywords
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