Tongue muscle regeneration

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Abstract
Rat tongues were injured by cold and the reactive processes were observed by light microscopy and EM. Injured animals and untreated controls were injected with aurothiomalate and the cells in tongue muscles which contained Au were observed after increasing injection-sacrifice time intervals. In the very rapid regeneration, Au-containing macrophage-like cells fused with each other and with well preserved parts of myofibers. The selectivity of Au localization suggested, at least morphologically, a macrophage to myoblast development. The possible factors affecting the rate of muscle regeneration were discussed with special reference to the nature of the injurious stimulus and the type of cellular response.

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