Comparative Effect of Intravenously Administered Nitrogenous Compounds on Uric Acid Synthesis in Chickens Fed a 20% Protein Diet

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Abstract
In order to examine a stimulatory effect of various nitrogenous compounds on uric acid synthesis in chickens, inosine, glutamine, asparagine, ammonium acetate, glycine, lysine, glutamic acid and threonine were infused into the portal vein of chickens fed a 20% protein diet. The nitrogenous compounds other than threonine significantly increased plasma uric acid concentration. Inosine increased plasma uric acid concentration the most, followed by glutamine, asparagine and ammonium acetate which had almost the same effect. Glycine was less effective in increasing plasma uric acid concentration than inosine, glutamine and asparagine, but still more effective than glutamic acid and lysine. A significant increase in urinary uric acid excretion was observed when inosine, glutamine, asparagine and ammonium acetate were infused, whereas no significant increase was observed when glycine and glutamic acid were infused. These results indicated that inosine, glutamine, asparagine and ammonium acetate might stimulate uric acid synthesis in chickens fed a 20% protein diet.