Experimental polymer storage disease in rabbits
- 1 January 1975
- journal article
- Published by Springer Nature in Virchows Archiv
- Vol. 365 (4) , 351-365
- https://doi.org/10.1007/bf00471182
Abstract
Water-soluble polymer compound, polyvinyl alcohol (PVA), and water-insoluble polymer compounds, polyvinyl acetate (PVAc) and polystylol (PS), were administered in 297 rabbits. When high polymerized PVA, PVAc or PS were continuously injected intravenously for a long period of time, lesions resembled to those of Gaucher and Niemann-Pick diseases were developed. From these experimental results, pathological development of various sphingolipidoseg found in the human body was discussed and pathological findings were analysed polymer-chemically from the chemical properties of the substances stored.Keywords
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