Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

1 May 1995

journal article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 39 (5) , 1204-1205
https://doi.org/10.1128/aac.39.5.1204

Abstract

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

Keywords

This publication has 11 references indexed in Scilit:

Analysis Of The Ul97 Phosphotransferase Coding Sequence In Clinical Cytomegalovirus Isolates And Identification Of Mutations Conferring Ganciclovir Resistance
The Journal of Infectious Diseases, 1995
Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.
Journal of Clinical Investigation, 1995
Ganciclovir Susceptibilities of Cytomegalovirus (CMV) Isolates from Solid Organ Transplant Recipients with CMV Viremia after Antiviral Prophylaxis
The Journal of Infectious Diseases, 1993
A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives
Antimicrobial Agents and Chemotherapy, 1993
A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
Nature, 1992
Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir
Antimicrobial Agents and Chemotherapy, 1991
Prevalence of Resistance in Patients Receiving Ganciclovir for Serious Cytomegalovirus Infection
The Journal of Infectious Diseases, 1991
Progressive Disease Due to Ganciclovir-Resistant Cytomegalovirus in Immunocompromised Patients
New England Journal of Medicine, 1989
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
Science, 1988
A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.
Proceedings of the National Academy of Sciences, 1986