Steric control of tautomerism in tetrapyrroles: iso-oxophlorins

Abstract
5-Oxophlorins possessing a 15-substituent (e.g. 5) tend to exist in the tautomeric iso-oxophlorin form 8 in order to minimize steric interactions between the 15-group and its abutting substituents; the structure of 8 is established by spectroscopic methods and by X-ray crystallography.

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