A comparison of prednisolone enemas with low-dose oral prednisolone in the treatment of acute distal ulcerative colitis
- 1 November 1984
- journal article
- research article
- Published by Wolters Kluwer Health in Diseases of the Colon & Rectum
- Vol. 27 (11) , 701-702
- https://doi.org/10.1007/bf02554591
Abstract
The therapeutic efficacy of prednisolone metasulfobenzoate enemas in the treatment of distal colitis was compared with that of low-dose oral prednisolone, in a single-blind, cross-over trial. Treatment with steroid enemas resulted in symptomatic and sigmoidoscopic evidence of improvement more frequently than treatment with a dosage of oral steroid calculated to achieve similar plasma prednisolone levels. Prednisolone mtasulfobenzoate enemas are effective in the treatment of colitis. Possibly, their efficacy is due to a local action rather than systemic absorption.This publication has 5 references indexed in Scilit:
- Rectally administered prednisolone--evidence for a predominantly local action.Gut, 1980
- Plasma prednisolone levels and adrenocortical responsiveness after administration of prednisolone-21-phosphate as a retention enema.Gut, 1979
- Plasma prednisolone levels after administration of prednisolone-21-phosphate as a retention enema in colitis.BMJ, 1976
- Intrarectal Treatment of 100 Cases of Ulcerative Colitis with Prednisolone-21-phosphate EnemataBMJ, 1961
- Cortisone in Ulcerative ColitisBMJ, 1955