Evaluation of the supertansfusion regimen in homozygous beta‐thalassaemia children

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Abstract
The maintenance of physiological levels of Hb is beneficial in the management of patients with thalassemia major since it leads to better tissue oxygenation, reduction of blood volume and reduced intestinal absorption of Fe. Patients (11) with thalassemia major were studied while being treated for 4-12 mo. with a standard transfusion regimen (mean pretranfusion Hb 10.2 g/dl) and then for a 2nd period of 7-18 mo. with a supertransfusion regimen (mean pre-transfusion Hb 12.3 g/dl). Blood consumption was 16.71 .+-. 2.0 ml/kg per mo. in the 1st period; it rose to 20.30 .+-. 3.5 ml/kg per mo. in the first 5 mo. of the 2nd period and then returned to the values of the 1st period (16.53 .+-. 2.0 ml/kg per mo.). There were no significant differences in blood consumption between the 2 transfusion regimens, after the 5-mo. equilibration period.