Conformation of tropolone ring in antileukemic tropoloisoquinoline alkaloids.

1 January 1993

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 41 (8) , 1478-1480
https://doi.org/10.1248/cpb.41.1478

Abstract

Conformational analysis of antileukemic tropoloisoquinoline alkaloids isolated from Cissampelos pareira was conducted by thermodynamic proton nuclear magnetic resonance (¹H NMR) studies. The line-broadening of one of methoxy methyl signals can be explained by the tropolone ring-puckering process. Analysis by dynamical simulated annealing and modified neglect of differential overlap (MNDO) calculations also supported puckering of tropolone ring system.

Keywords

PROTON
ALKALOIDS
ANNEALING
RESONANCE
TROPOLOISOQUINOLINE
DIFFERENTIAL
CONFORMATIONAL
ANTILEUKEMIC
TROPOLONE RING

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