Molecular cloning and evolutional analysis of a mammalian homologue of theDistal-less 3(Dlx-3) homeobox gene
- 12 September 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 351 (3) , 380-384
- https://doi.org/10.1016/0014-5793(94)00896-5
Abstract
We have cloned and sequenced a cDNA encoding the mammalian homologue of Distal‐less 3 (Dlx‐3) from a rat embryonic brain cDNA library. The primary structure of rat Dlx‐3 showed a cDNA with an open reading frame of 290 amino acids with a molecular weight of 31 kDa harboring a homeodomain sequence characteristic of the Distal‐less homoeobox gene. In addition to the highly conserved homeodomain sequence, we newly found the consensus motifs in the N‐terminal and C‐terminal region, which were specifically conserved among Distal‐less members of different species. Phylogenetic analysis of the Distal‐less homeodomain sequence also showed a possible association between the sequence similarities in the homeodomain and the spatial specifications of homeobox genes expressed in the developing central nervous system.Keywords
This publication has 17 references indexed in Scilit:
- Gene expression of CD24 core peptide molecule in developing brain and developing non‐neural tissuesDevelopmental Dynamics, 1993
- Two distal-less related homeobox-containing genes expressed in regeneration blastemas of the newtDevelopmental Biology, 1992
- Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-lessCell, 1992
- Regional expression of three homeobox transcripts in the inner ear of zebrafish embryosNeuron, 1992
- The homeodomain: A new face for the helix‐turn‐helix?BioEssays, 1992
- Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrainNeuron, 1991
- A mouse gene related to Distal-less shows a restricted expression in the developing forebrainNature, 1991
- Mediation of Drosophila head development by gap-like segmentation genesNature, 1990
- Distal-less encodes a homoeodomain protein required for limb development in DrosophilaNature, 1989
- DNA sequencing with chain-terminating inhibitorsProceedings of the National Academy of Sciences, 1977