An Immunohistochemical Study on the Embryonic Development of Renin‐containing Cells in the Mouse and Pig

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Abstract
Summary: The prenatal occurrence and distribution of renin‐containing (RC) cells were investigated immunohistochemically in mouse and pig embryos.The RC cells of the mouse embryo were first observed at the 13th day of gestation at the walls of the renal, the mesonephric, the adrenal, the abdominal arteries, the adrenal glands and the testis. As the gestation of the mouse progressed, the RC cells had a tendency to localize in areas of the vascular pole of the metanephric glomerulus. In pig, when CRL was 0.8–2.0cm, RC cells first appeared at the ventral walls of the dorsal aorta, the omphalo‐mesenteric (i.e., the cranial mesenteric), the mesonephric, the mesonephric afferent glomerular arteries/arterioles and the inside of the mesonephric glomenilus. As the length of the pig embryo increased, no renin‐immunoreactivity could be demonstrated at the degenerated mesonephros, while in the metanephros marked immunoreactivities were found only at the terminal regions of intralobular arteries, i. e., afferent arterioles or the vascular pole of the glomerulus.