6-Aminopenicillanic acid IV. Antibacterial activity
- 15 August 1961
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 154 (957) , 509-513
- https://doi.org/10.1098/rspb.1961.0048
Abstract
6-Aminopenicillanic acid shows a similar order of activity against the Gram-positive cocci as against the Gram-negative bacilli. Compared with benzylpenicillin, the activity against the Gram-positive cocci is very low but against the Gram-negative bacilli, 6-aminopenicillanic acid shows a similar order of activity to benzylpenicillin. 6-Aminopenicillanic acid is bactericidal at concentrations only slightly higher than the minimum inhibitory concentrations. Like benzylpenicillin, 6-aminopenicillanic acid appears to interfere with cell wall formation. Staphylococci trained to be resistant to 6-aminopenicillanic acid show resistance to benzylpenicillin and vice versa.This publication has 8 references indexed in Scilit:
- An Investigation into the Development of Gram-negative rods in Penicillin-treated Cultures of Staphylococcus aureusJournal of General Microbiology, 1959
- Further Observations on the Relationships between Gram-Negative Rods and Staphylococci Grown in the Presence of PenicillinJournal of General Microbiology, 1959
- Attempts to Obtain Gram-Negative Rods from Staphylococci Treated with PenicillinJournal of General Microbiology, 1959
- Some Properties of Gram-negative Bacilli Obtained from a Strain of Staphylococcus aureus in the Presence of BenzylpenicillinJournal of General Microbiology, 1957
- Mode of Action of PenicillinScience, 1957
- The Low Therapeutic Activity of Penicillin K Relative to That of Penicillins F, G, and X, and Its Pharmacological BasisScience, 1946
- The Activity of Penicillins G and X in VitroScience, 1945
- Morphological Effects of Penicillin on BacteriaNature, 1940