Effect of Hyperoxide Radicals on Bovine-Erythrocyte Membrane

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Abstract
Bovine erythrocytes exposed to the action of an enzymic source of hyperoxide radicals (hypoxanthine + xanthine oxidase [EC 1.2.3.2]) exhibited hemolysis, which was prevented by the presence of hyperoxide dismutase [EC 1.15.1.1]. Exposing bovine erythrocyte membranes to the source of hyperoxide radicals resulted in a decrease of (Mg2+ + Na+ + K+)-ATPase [EC 3.6.1.3] activity which could be partially prevented by addition of hyperoxide dismutase. The damage observed to erythrocyte membranes under the conditions applied is ascribed to .OH formed in the Haber and Weiss reaction since a protection by .OH scavengers was also observed.

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