Adenosine and adenosine analogues increase blood flow in oral mucosa

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Abstract
The effect of adenosine and some related compounds was studied on blood flow in feline oral mucosa. Changes in the rate of disappearance of 125Iodide (k-value) from a local depot in the oral mucosa was used to determine changes in the mucosal blood flow. Infusion of adenosine caused a dose-dependent increase of blood flow. Two stable adenosine analogs, adenosine 5''-ethylcarboxamide (NECA) and L-phenylisopropyl-adenosine (L-PIA), were 20 and 10 times more potent than the parent compound. Dipyridamole (2 mg/kg), which blocks adenosine uptake, significantly enhanced the potency of adenosine. Theophylline (10 mg/kg) inhibited the vasodilatory effect of adenosine and of the adenosine analogs. Adenosine may be involved in the regulation of blood flow in the oral mucosa.

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