Hormone-Negative, Chromogranin a-Positive Endocrine Tumors

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Abstract
THE overproduction of hormones by endocrine tumors contributes to their clinical manifestations and serves as the basis of diagnostic testing.1 We describe tumors of three different endocrine tissues — medullary thyroid carcinoma, anterior pituitary adenoma, and pancreatic islet-cell carcinoma — that did not produce their resident hormones (hormone-negative) but did produce chromogranin A (chromogranin A–positive). Chromogranin A is a 439-amino-acid protein encoded on chromosome 14 that is produced by a variety of normal and malignant neuroendocrine cells but not by non-endocrine cells.2 3 4 5 Chromogranin A is overproduced and released into the circulation by endocrine tumors and has consequently become a marker . . .

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