Effects of Opioid and α2-Adrenoceptor Agonists on the Isolated Ileum of Morphine-dependent Guinea-pigs During Withdrawal and After Clonidine Treatment

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Abstract
The present study was undertaken to investigate the effect of clonidine administration to opiate-dependent guinea-pigs after morphine withdrawal on subsequent twitch responses of the longitudinal muscle-myenteric plexus preparations to electrical field stimulation. The results indicate that clonidine, administered immediately after morphine removal, causes tolerance to the inhibition exerted by opioid and α2-adrenoceptor agonists on the electrically-evoked twitches. Such a finding suggests that the mechanism of action of clonidine involves not only its well-known effects on locus coeruleus neurons but also that it has specific actions on the myenteric plexus. This work shows the existence of interactions between opioid and α-adrenoceptor on the cholinergic neurons present in the isolated ileum.