Neuropsychiatric Side Effects of Mefloquine

Publisher Website
Google Scholar
Abstract
In a pharmacokinetic study by Patchen et al. (Nov. 16 issue),1 four of seven subjects given mefloquine base (13.5 to 15.4 mg per kilogram of body weight) experienced dizziness, and three also had vertigo. Indeed, analysis of registration documents indicated that dizziness occurred in 24 percent of patients with malaria treated with 750 mg of mefloquine, in 38 percent treated with 1000 mg, and in 96 percent treated with 1500 mg. Dividing a 1250-mg dose into two doses given eight hours apart reduced the incidence of dizziness to 23 percent.2

This publication has 1 reference indexed in Scilit: